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Based on a relatively extensive database in experimental animals, 2-methoxyethanol has consistently been associated with a wide range of adverse effects on health, including those considered to be severe and irreversible (e.g., teratogenicity), with some occurring at relatively low levels of exposure. However, although relevant data are limited, exposure of the general population through environmental media is expected to be low, due to reported declining use of the compound in recent years as it is replaced with less hazardous compounds. Margins between worst-case estimates of exposure from environmental media and lowest effect levels for developmental toxicity obtained in toxicological investigations in experimental animals are large. However, available data are insufficient to conclude that margins between worst-case estimates of exposure in consumer products and lowest effect levels are adequate.
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