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  External Seminar Dr. Al...  
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External Seminar Dr. Albert LEE
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Séminaire externe Dr. Albert LEE
  NICE2 : épilepsies et e...  
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• in the context of an international consortium, we have also identified mutations in the Proline-Rich Repeat Protein PRRT2 as the major genetic cause for the variable comorbid association of infantile convulsions, paroxysmal dyskinesia and hemiplegic migraine, which had been searched for more than 15 years (Lee et al. Cell Reports 2012; Cloarec et al. Neurology 2012).
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We use multidisciplinary approaches and tools that non exhaustively include molecular genetics, cell biology, flow cytometry, protein analysis, electrophysiological recordings in vitro and in vivo, intracerebroventicular electroporation and infection of the embryonic brain in utero, behavioral analyses, rescue strategies in vivo, 2-photon microscopy, cellular and rodent models, etc.