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  AtGLR-Projekt Biochemie...  
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Iono­tro­pe Glu­ta­mat­re­zep­to­ren sind in Tie­ren be­reits lange be­kannt. Im Ge­hirn der Wir­bel­tie­re spie­len die­se li­gan­den­ak­ti­vier­ten Ionen­ka­nä­le ei­ne ent­schei­den­de Rol­le in der Kom­mu­ni­ka­tion zwi­schen Ner­ven­zel­len.
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Ionotropic glutamate receptors have long been known in animals. These ligand-gated ion channels play a major role in the communication between neurons in the vertebrate brain. Surprisingly, putative glutamate receptor genes were also discovered in an organism lacking a nervous system - the plant
  Stammzell-Projekt Bioch...  
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Bei der Ent­wick­lung des Ge­hirns spie­len elek­tri­sche Sig­na­le ei­ne wich­ti­ge Rol­le, z.B. für die Bil­dung von Ver­knüp­fungen zwi­schen Ner­ven­zel­len. Die­se elek­tri­schen Sig­na­le wer­den u.a. durch Glu­ta­mat­re­zep­to­ren ver­mit­telt.
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Electrical signals play an important role during brain development, e.g. in the formation of connections between neurons. These electrical signals are partly mediated by glutamate receptors. The exact receptor composition and the role of particular subunits are difficult to study in the brain itself. Therefore, we use embryonic stem cells as a model system to analyse the importance of particular glutamate receptors for the differentiation to neurons. more...
  DVCS  
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Die Deutsche Vereinigung für China­stu­dien e.V. (DVCS) mit Sitz in Ber­lin wur­de im Früh­jahr 1990 an der Hum­boldt-Uni­ver­si­tät zu Ber­lin von Chi­na­wis­sen­schaft­lern aus der DDR und der Bun­des­re­pub­lik mit dem Ziel ge­grün­det, nach dem Weg­fall der in­ner­deut­schen Gren­ze die Ent­wick­lung der Chi­na­stu­dien in Deutsch­land durch einen ver­stärkten per­sönlichen und fach­li­chen Aus­tausch zu fördern.
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The German Association of Chinese Studies (DVCS), based in Ber­lin, was found­ed at the Hum­boldt Uni­ver­si­ty of Ber­lin by schol­ars of Chi­nese stud­ies from the Ger­man De­mo­cra­tic Re­pub­lic and the Fe­de­ral Re­pub­lic of Ger­ma­ny in spring 1990, with the aim of pro­mot­ing Chi­nese Stud­ies in Ger­many, fol­low­ing the abo­lish­ment of the in­ner Ger­man bor­der, through joint schol­ar­ly ac­ti­vi­ties and aca­dem­ic ex­changes. The an­nual DVCS con­fe­ren­ces help to achie­ve this aim by ser­ving as a plat­form for the pre­sen­ta­tion of new re­search re­sults and for aca­dem­ic dis­cus­sions, not only for mem­bers of the as­so­ci­a­tion but also for all who are in­ter­es­ted in Chi­na. The DVCS at­taches spe­cial im­por­tance to pro­vid­ing a dis­cus­sion fo­rum for young Si­no­lo­gists, an or­ga­ni­za­tio­nal roof for re­search pro­jects, and op­por­tu­ni­ties for pub­li­ca­tion. As a rec­og­nized non-prof­it or­gan­iza­tion, the DVCS acts al­tru­is­ti­cal­ly and does not pur­sue e­con­o­mic or par­ty-po­lit­i­cal ob­jec­tives. [Ap­pli­ca­tion for mem­ber­ship | By-laws]
  TARP-Projekt Biochemie ...  
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AMPA-Re­zep­to­ren sind ei­ne Un­ter­fa­mi­lie der Glu­ta­mat­re­zep­to­ren und spie­len ei­ne ent­schei­den­de Rol­le in der schnel­len Sig­nal­wei­ter­lei­tung im Ge­hirn. Ob­wohl AMPA-Re­zep­to­ren ih­re grund­le­gen­de Funk­ti­on, näm­lich bei Bin­dung von Glu­ta­mat Ionen in die Zel­le zu lei­ten, al­lei­ne aus­üben kön­nen, sind an der Fein­ab­stim­mung die­ses Pro­zes­ses ei­ne Rei­he an­de­rer Pro­te­ine be­tei­ligt.
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AMPA receptors are a subfamily of ionotropic glutamate receptors and play a crucial role in fast signal transduction in the brain. Although AMPA receptors can exert their basic function, i.e., fluxing ions into the cell upon binding of glutamate, on their own, many other proteins are involved in the fine tuning of this process. Most of these proteins are important for transporting the AMPA receptors to their correct destination when they are needed, but also for removing them when they are not needed any more. The discovery of a family of six small membrane proteins that are also involved in this regulation of transport, but in addition directly change the functional properties of AMPA receptors, was a surprising achievement. In particular, these transmembrane AMPA receptor regulatory proteins (TARPs) boost the glutamate-induced signal by increasing the opening time of the AMPA receptor channel. To understand the function of AMPA receptors, it is important to understand this mechanism. We are particularly interested in characterising the different impacts of the different TARPs on AMPA receptors and investigate the interactions that form the basis of this differential modulation.
  TARP-Projekt Biochemie ...  
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AMPA-Re­zep­to­ren sind ei­ne Un­ter­fa­mi­lie der Glu­ta­mat­re­zep­to­ren und spie­len ei­ne ent­schei­den­de Rol­le in der schnel­len Sig­nal­wei­ter­lei­tung im Ge­hirn. Ob­wohl AMPA-Re­zep­to­ren ih­re grund­le­gen­de Funk­ti­on, näm­lich bei Bin­dung von Glu­ta­mat Ionen in die Zel­le zu lei­ten, al­lei­ne aus­üben kön­nen, sind an der Fein­ab­stim­mung die­ses Pro­zes­ses ei­ne Rei­he an­de­rer Pro­te­ine be­tei­ligt.
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AMPA receptors are a subfamily of ionotropic glutamate receptors and play a crucial role in fast signal transduction in the brain. Although AMPA receptors can exert their basic function, i.e., fluxing ions into the cell upon binding of glutamate, on their own, many other proteins are involved in the fine tuning of this process. Most of these proteins are important for transporting the AMPA receptors to their correct destination when they are needed, but also for removing them when they are not needed any more. The discovery of a family of six small membrane proteins that are also involved in this regulation of transport, but in addition directly change the functional properties of AMPA receptors, was a surprising achievement. In particular, these transmembrane AMPA receptor regulatory proteins (TARPs) boost the glutamate-induced signal by increasing the opening time of the AMPA receptor channel. To understand the function of AMPA receptors, it is important to understand this mechanism. We are particularly interested in characterising the different impacts of the different TARPs on AMPA receptors and investigate the interactions that form the basis of this differential modulation.
  TARP-Projekt Biochemie ...  
Show textShow cached sourceOpen source URL
AMPA-Re­zep­to­ren sind ei­ne Un­ter­fa­mi­lie der Glu­ta­mat­re­zep­to­ren und spie­len ei­ne ent­schei­den­de Rol­le in der schnel­len Sig­nal­wei­ter­lei­tung im Ge­hirn. Ob­wohl AMPA-Re­zep­to­ren ih­re grund­le­gen­de Funk­ti­on, näm­lich bei Bin­dung von Glu­ta­mat Ionen in die Zel­le zu lei­ten, al­lei­ne aus­üben kön­nen, sind an der Fein­ab­stim­mung die­ses Pro­zes­ses ei­ne Rei­he an­de­rer Pro­te­ine be­tei­ligt.
Compare text pagesCompare HTM pagesOpen source URLOpen target URLDefine ruhr-uni-bochum.de as primary domain
AMPA receptors are a subfamily of ionotropic glutamate receptors and play a crucial role in fast signal transduction in the brain. Although AMPA receptors can exert their basic function, i.e., fluxing ions into the cell upon binding of glutamate, on their own, many other proteins are involved in the fine tuning of this process. Most of these proteins are important for transporting the AMPA receptors to their correct destination when they are needed, but also for removing them when they are not needed any more. The discovery of a family of six small membrane proteins that are also involved in this regulation of transport, but in addition directly change the functional properties of AMPA receptors, was a surprising achievement. In particular, these transmembrane AMPA receptor regulatory proteins (TARPs) boost the glutamate-induced signal by increasing the opening time of the AMPA receptor channel. To understand the function of AMPA receptors, it is important to understand this mechanism. We are particularly interested in characterising the different impacts of the different TARPs on AMPA receptors and investigate the interactions that form the basis of this differential modulation.